Drug interactions
Clorazepate + Levetiracetam
Severity: Minor
Clorazepate and Levetiracetam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause somnolence and dizziness, so the combination can increase drowsiness, fatigue and impaired coordination. It is commonly used in epilepsy, and the effect often lessens with time.
What this interaction means in plain words
Clorazepate and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clorazepate belongs to Central Nervous System; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through different mechanisms: GABA-A potentiation and SV2A binding.
What to do
Monitor for sedation and dizziness when starting or increasing either drug, and advise caution with driving until the response is known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Levetiracetam
Frequently asked questions
Can I take Clorazepate with Levetiracetam?
MediHelp rates the interaction as minor. Clorazepate and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs cause somnolence and dizziness, so the combination can increase drowsiness, fatigue and impaired coordination. It is commonly used in epilepsy, and the effect often lessens with time.
How serious is the interaction between Clorazepate and Levetiracetam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and dizziness when starting or increasing either drug, and advise caution with driving until the response is known.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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