Drug interactions
Clorazepate + Methocarbamol
Severity: Moderate
Clorazepate and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clorazepate is a benzodiazepine whose active metabolite is long acting. Combined with methocarbamol it can produce excess sedation, dizziness and impaired psychomotor performance.
What this interaction means in plain words
Clorazepate and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depression from a benzodiazepine and a centrally acting muscle relaxant.
What to do
Use the lowest effective doses and monitor for oversedation and respiratory depression, especially in older adults. Advise avoiding alcohol and driving until response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Clorazepate with Methocarbamol?
MediHelp rates the interaction as moderate. Clorazepate and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clorazepate is a benzodiazepine whose active metabolite is long acting. Combined with methocarbamol it can produce excess sedation, dizziness and impaired psychomotor performance.
How serious is the interaction between Clorazepate and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and respiratory depression, especially in older adults. Advise avoiding alcohol and driving until response is known.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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