Drug interactions
Clorazepate + Mitotane
Severity: Moderate
Clorazepate and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and can substantially lower concentrations of clorazepate's active metabolite, reducing its efficacy. Loss of anticonvulsant or anxiolytic control may occur, and the induction persists for weeks after mitotane is stopped.
What this interaction means in plain words
Clorazepate and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Mitotane belongs to Oncology.
Why it happens
Induction of CYP3A4 by mitotane increases metabolism of nordiazepam.
What to do
Monitor clinical response and increase the clorazepate dose if needed. Reassess the dose after mitotane is discontinued as induction wanes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Clorazepate with Mitotane?
MediHelp rates the interaction as moderate. Clorazepate and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and can substantially lower concentrations of clorazepate's active metabolite, reducing its efficacy. Loss of anticonvulsant or anxiolytic control may occur, and the induction persists for weeks after mitotane is stopped.
How serious is the interaction between Clorazepate and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the clorazepate dose if needed. Reassess the dose after mitotane is discontinued as induction wanes.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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