Drug interactions
Clorazepate + Ramelteon
Severity: Minor
Clorazepate and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon is a melatonin receptor agonist with mild sedative effects, so some additive drowsiness with clorazepate is possible. The interaction is generally mild, with no clear pharmacokinetic effect.
What this interaction means in plain words
Clorazepate and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clorazepate belongs to Central Nervous System; Ramelteon belongs to Central Nervous System.
Why it happens
Mild additive sedation from melatonin receptor agonism with GABA-A potentiation.
What to do
No dose change is usually required. Advise patients about next-day drowsiness and avoiding driving if impaired.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Clorazepate with Ramelteon?
MediHelp rates the interaction as minor. Clorazepate and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon is a melatonin receptor agonist with mild sedative effects, so some additive drowsiness with clorazepate is possible. The interaction is generally mild, with no clear pharmacokinetic effect.
How serious is the interaction between Clorazepate and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Advise patients about next-day drowsiness and avoiding driving if impaired.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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