Drug interactions
Clorazepate + Rifapentine
Severity: Moderate
Clorazepate and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4 and may reduce exposure to clorazepate's active metabolite, weakening its clinical effect. Dose requirements may rise during treatment and fall again after rifapentine is stopped.
What this interaction means in plain words
Clorazepate and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clorazepate belongs to Central Nervous System; Rifapentine belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 by rifapentine increases metabolism of clorazepate's active metabolite.
What to do
Monitor for loss of benzodiazepine effect and adjust the dose as needed. Re-evaluate the dose after rifapentine is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Clorazepate with Rifapentine?
MediHelp rates the interaction as moderate. Clorazepate and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces CYP3A4 and may reduce exposure to clorazepate's active metabolite, weakening its clinical effect. Dose requirements may rise during treatment and fall again after rifapentine is stopped.
How serious is the interaction between Clorazepate and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of benzodiazepine effect and adjust the dose as needed. Re-evaluate the dose after rifapentine is discontinued.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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