Drug interactions
Clotrimazole + Midazolam
Severity: Minor
Clotrimazole and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic exposure to clotrimazole from topical or vaginal products is low, so little interaction is expected. Oral lozenge use may produce modest CYP3A4 inhibition, but evidence is limited.
What this interaction means in plain words
Clotrimazole and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clotrimazole belongs to Anti Fungals; Midazolam belongs to Central Nervous System.
Why it happens
Possible CYP3A4 inhibition by clotrimazole, with limited systemic availability.
What to do
Usually no change needed; monitor sedation if clotrimazole is given systemically or as lozenges with oral midazolam.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clotrimazole and Midazolam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Clotrimazole
- Clotrimazole + Lomitapide Major
- Clotrimazole + Mavacamten Major
- Clotrimazole + Mobocertinib Major
- Clotrimazole + Voclosporin Major
- Bosutinib + Clotrimazole Moderate
- Cannabidiol + Clotrimazole Moderate
Frequently asked questions
Can I take Clotrimazole with Midazolam?
MediHelp rates the interaction as minor. Clotrimazole and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic exposure to clotrimazole from topical or vaginal products is low, so little interaction is expected. Oral lozenge use may produce modest CYP3A4 inhibition, but evidence is limited.
How serious is the interaction between Clotrimazole and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change needed; monitor sedation if clotrimazole is given systemically or as lozenges with oral midazolam.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
