Drug interactions
Clozapine + Dantrolene
Severity: Moderate
Clozapine and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both dantrolene and clozapine can cause marked drowsiness. Combined use may deepen sedation and impair alertness, and in vulnerable patients may add to dizziness and falls.
What this interaction means in plain words
Clozapine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for oversedation and orthostatic symptoms, particularly during initiation or dose increases of either drug. Reduce the dose of one agent if daytime sedation becomes troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Dantrolene?
MediHelp rates the interaction as moderate. Clozapine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both dantrolene and clozapine can cause marked drowsiness. Combined use may deepen sedation and impair alertness, and in vulnerable patients may add to dizziness and falls.
How serious is the interaction between Clozapine and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and orthostatic symptoms, particularly during initiation or dose increases of either drug. Reduce the dose of one agent if daytime sedation becomes troublesome.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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