Drug interactions
Clozapine + Dihydroergotamine
Severity: Moderate
Clozapine and Dihydroergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine is a serotonergic agent, and use with antipsychotics has been linked in theory to serotonin syndrome or neuroleptic malignant syndrome. Dihydroergotamine is also a vasoconstrictor whose levels rise with CYP3A4 inhibitors, which matters if other interacting drugs are used.
What this interaction means in plain words
Clozapine and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Additive serotonergic and dopaminergic effects; mechanism not well established.
What to do
Monitor for agitation, tremor, hyperthermia, muscle rigidity and autonomic instability after starting. Avoid concurrent CYP3A4 inhibitors with dihydroergotamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Clozapine with Dihydroergotamine?
MediHelp rates the interaction as moderate. Clozapine and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine is a serotonergic agent, and use with antipsychotics has been linked in theory to serotonin syndrome or neuroleptic malignant syndrome. Dihydroergotamine is also a vasoconstrictor whose levels rise with CYP3A4 inhibitors, which matters if other interacting drugs are used.
How serious is the interaction between Clozapine and Dihydroergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, muscle rigidity and autonomic instability after starting. Avoid concurrent CYP3A4 inhibitors with dihydroergotamine.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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