Drug interactions
Clozapine + Dolasetron
Severity: Moderate
Clozapine and Dolasetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and clozapine also carries risks of myocarditis and tachyarrhythmia. Combined use may increase the likelihood of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Clozapine and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Dolasetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation.
What to do
Correct electrolytes and consider an ECG before and after starting dolasetron. Prefer an alternative antiemetic in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Dolasetron?
MediHelp rates the interaction as moderate. Clozapine and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and clozapine also carries risks of myocarditis and tachyarrhythmia. Combined use may increase the likelihood of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Clozapine and Dolasetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct electrolytes and consider an ECG before and after starting dolasetron. Prefer an alternative antiemetic in patients with cardiac risk factors.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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