Drug interactions
Clozapine + Esomeprazole
Severity: Minor
Clozapine and Esomeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esomeprazole is not a recognized CYP1A2 inhibitor or inducer, and no meaningful change in clozapine levels is established. Omeprazole has been reported to affect CYP1A2, but this is not well supported for esomeprazole.
What this interaction means in plain words
Clozapine and Esomeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clozapine belongs to Central Nervous System; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Possible weak CYP1A2 effect; not an established mechanism.
What to do
No empirical dose change is needed. Monitor clinical response if the PPI is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Esomeprazole?
MediHelp rates the interaction as minor. Clozapine and Esomeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Esomeprazole is not a recognized CYP1A2 inhibitor or inducer, and no meaningful change in clozapine levels is established. Omeprazole has been reported to affect CYP1A2, but this is not well supported for esomeprazole.
How serious is the interaction between Clozapine and Esomeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor clinical response if the PPI is started or stopped.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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