Drug interactions
Clozapine + Glipizide
Severity: Moderate
Clozapine and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine often causes weight gain, insulin resistance and hyperglycemia, which can reduce the effectiveness of glipizide. Diabetic control may worsen, and hyperglycemic crises are possible.
What this interaction means in plain words
Clozapine and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Glipizide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, as clozapine induces insulin resistance and impairs glucose regulation.
What to do
Monitor blood glucose and HbA1c regularly, particularly after starting or changing clozapine. Titrate glipizide or add other agents as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clozapine and Glipizide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Glipizide
Frequently asked questions
Can I take Clozapine with Glipizide?
MediHelp rates the interaction as moderate. Clozapine and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine often causes weight gain, insulin resistance and hyperglycemia, which can reduce the effectiveness of glipizide. Diabetic control may worsen, and hyperglycemic crises are possible.
How serious is the interaction between Clozapine and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c regularly, particularly after starting or changing clozapine. Titrate glipizide or add other agents as required.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
