Drug interactions
Clozapine + Goserelin
Severity: Moderate
Clozapine and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with goserelin can prolong the QT interval, and clozapine may add to this effect. The combination may raise the risk of torsades de pointes, especially with electrolyte disturbance or heart disease.
What this interaction means in plain words
Clozapine and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Goserelin belongs to Endocrine.
Why it happens
Additive QT prolongation through different mechanisms.
What to do
Obtain a baseline ECG and repeat periodically during treatment, and maintain normal potassium and magnesium. Avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Goserelin
Frequently asked questions
Can I take Clozapine with Goserelin?
MediHelp rates the interaction as moderate. Clozapine and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with goserelin can prolong the QT interval, and clozapine may add to this effect. The combination may raise the risk of torsades de pointes, especially with electrolyte disturbance or heart disease.
How serious is the interaction between Clozapine and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat periodically during treatment, and maintain normal potassium and magnesium. Avoid adding other QT-prolonging drugs.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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