Drug interactions
Clozapine + Indacaterol
Severity: Moderate
Clozapine and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine can prolong the QT interval and cause tachycardia and, rarely, myocarditis or cardiomyopathy. Indacaterol may add to tachycardia and arrhythmic risk.
What this interaction means in plain words
Clozapine and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Indacaterol belongs to Respiratory.
Why it happens
Additive QT prolongation and sympathomimetic cardiac stimulation.
What to do
Monitor heart rate, ECG and electrolytes in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Indacaterol?
MediHelp rates the interaction as moderate. Clozapine and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine can prolong the QT interval and cause tachycardia and, rarely, myocarditis or cardiomyopathy. Indacaterol may add to tachycardia and arrhythmic risk.
How serious is the interaction between Clozapine and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and electrolytes in patients with cardiac risk factors.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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