Drug interactions
Clozapine + Lenvatinib
Severity: Moderate
Clozapine and Lenvatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenvatinib prolongs the QT interval and clozapine can also affect cardiac repolarization. The combination may increase the risk of torsades de pointes, especially with electrolyte abnormalities.
What this interaction means in plain words
Clozapine and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Lenvatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG and electrolytes (potassium, magnesium, calcium) at baseline and periodically. Correct abnormalities and interrupt or reduce lenvatinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Clozapine with Lenvatinib?
MediHelp rates the interaction as moderate. Clozapine and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenvatinib prolongs the QT interval and clozapine can also affect cardiac repolarization. The combination may increase the risk of torsades de pointes, especially with electrolyte abnormalities.
How serious is the interaction between Clozapine and Lenvatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes (potassium, magnesium, calcium) at baseline and periodically. Correct abnormalities and interrupt or reduce lenvatinib if QTc becomes markedly prolonged.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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