Drug interactions
Clozapine + Methamphetamine
Severity: Moderate
Clozapine and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine's sedating and antidopaminergic effects oppose methamphetamine, which may reduce the efficacy of either drug. Both can cause tachycardia and affect blood pressure, and clozapine carries cardiac risks such as myocarditis and QT effects.
What this interaction means in plain words
Clozapine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine and adrenergic receptors with overlapping cardiovascular effects.
What to do
Monitor heart rate, blood pressure, and psychiatric status, and obtain an ECG if cardiac symptoms occur. Watch for worsening psychosis in patients with psychotic disorders.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Methamphetamine?
MediHelp rates the interaction as moderate. Clozapine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine's sedating and antidopaminergic effects oppose methamphetamine, which may reduce the efficacy of either drug. Both can cause tachycardia and affect blood pressure, and clozapine carries cardiac risks such as myocarditis and QT effects.
How serious is the interaction between Clozapine and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure, and psychiatric status, and obtain an ECG if cardiac symptoms occur. Watch for worsening psychosis in patients with psychotic disorders.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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