Drug interactions
Clozapine + Midodrine
Severity: Minor
Clozapine and Midodrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist that can counteract clozapine-induced orthostatic hypotension, and the sedation concern in the legacy entry is not established. Combined use may raise blood pressure unpredictably and cause supine hypertension or reflex bradycardia.
What this interaction means in plain words
Clozapine and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clozapine belongs to Central Nervous System; Midodrine belongs to Miscellaneous.
Why it happens
Opposing effects at alpha-1 adrenergic receptors (clozapine blocks, midodrine activates).
What to do
Monitor supine and standing blood pressure, and avoid dosing midodrine near bedtime.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clozapine and Midodrine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Clozapine with Midodrine?
MediHelp rates the interaction as minor. Clozapine and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Midodrine is an alpha-1 agonist that can counteract clozapine-induced orthostatic hypotension, and the sedation concern in the legacy entry is not established. Combined use may raise blood pressure unpredictably and cause supine hypertension or reflex bradycardia.
How serious is the interaction between Clozapine and Midodrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure, and avoid dosing midodrine near bedtime.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
