Drug interactions
Clozapine + Ozanimod
Severity: Moderate
Clozapine and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and conduction, and clozapine can prolong the QT interval and cause tachycardia or myocarditis. Combined use may increase the arrhythmia risk.
What this interaction means in plain words
Clozapine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Additive effects on cardiac conduction and repolarization.
What to do
Obtain an ECG before starting ozanimod and seek cardiology advice if QT-prolonging drugs are needed. Monitor heart rate and rhythm during initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Clozapine with Ozanimod?
MediHelp rates the interaction as moderate. Clozapine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and conduction, and clozapine can prolong the QT interval and cause tachycardia or myocarditis. Combined use may increase the arrhythmia risk.
How serious is the interaction between Clozapine and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting ozanimod and seek cardiology advice if QT-prolonging drugs are needed. Monitor heart rate and rhythm during initiation.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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