Drug interactions
Clozapine + Rucaparib
Severity: Moderate
Clozapine and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate inhibitor of CYP1A2 and may raise clozapine plasma concentrations. Higher exposure can increase sedation, hypotension, seizure risk and other dose-related clozapine adverse effects.
What this interaction means in plain words
Clozapine and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP1A2, the main enzyme responsible for clozapine clearance.
What to do
Monitor for clozapine toxicity (sedation, hypotension, seizures) and consider checking clozapine levels when rucaparib is started or stopped. Reduce the clozapine dose if clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Clozapine with Rucaparib?
MediHelp rates the interaction as moderate. Clozapine and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a moderate inhibitor of CYP1A2 and may raise clozapine plasma concentrations. Higher exposure can increase sedation, hypotension, seizure risk and other dose-related clozapine adverse effects.
How serious is the interaction between Clozapine and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clozapine toxicity (sedation, hypotension, seizures) and consider checking clozapine levels when rucaparib is started or stopped. Reduce the clozapine dose if clinically indicated.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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