Drug interactions
Clozapine + Tiotropium-olodaterol
Severity: Moderate
Clozapine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is strongly anticholinergic, so combining it with tiotropium can add to constipation, urinary retention and dry mouth, and severe constipation or ileus is a recognized clozapine risk. Clozapine also prolongs the QT interval, and beta2 stimulation may add to arrhythmia risk.
What this interaction means in plain words
Clozapine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive antimuscarinic effects and additive QT prolongation with beta2 sympathetic stimulation.
What to do
Monitor bowel function and urinary symptoms and counsel patients to report constipation promptly. Obtain an ECG in patients with cardiac risk factors and keep electrolytes normal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Clozapine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Clozapine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is strongly anticholinergic, so combining it with tiotropium can add to constipation, urinary retention and dry mouth, and severe constipation or ileus is a recognized clozapine risk. Clozapine also prolongs the QT interval, and beta2 stimulation may add to arrhythmia risk.
How serious is the interaction between Clozapine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and urinary symptoms and counsel patients to report constipation promptly. Obtain an ECG in patients with cardiac risk factors and keep electrolytes normal.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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