Drug interactions
Cobicistat + Edoxaban
Severity: Moderate
Cobicistat and Edoxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits P-gp and CYP3A4, which can increase edoxaban concentrations. The higher exposure raises the risk of bleeding.
What this interaction means in plain words
Cobicistat and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Edoxaban belongs to Cardiovascular.
Why it happens
Inhibition of intestinal and renal P-gp efflux of edoxaban, with minor CYP3A4 effect.
What to do
Monitor for bleeding and renal function. Follow edoxaban labeling for P-gp inhibitors, and consider an alternative anticoagulant if bleeding risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Edoxaban?
MediHelp rates the interaction as moderate. Cobicistat and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits P-gp and CYP3A4, which can increase edoxaban concentrations. The higher exposure raises the risk of bleeding.
How serious is the interaction between Cobicistat and Edoxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and renal function. Follow edoxaban labeling for P-gp inhibitors, and consider an alternative anticoagulant if bleeding risk is high.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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