Drug interactions
Cobicistat + Haloperidol
Severity: Major
Cobicistat and Haloperidol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 and CYP2D6 inhibitor and can raise haloperidol concentrations, increasing the risk of QT prolongation, sedation and extrapyramidal effects.
What this interaction means in plain words
Cobicistat and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cobicistat belongs to Miscellaneous; Haloperidol belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 and CYP2D6 metabolism of haloperidol.
What to do
Start haloperidol at a low dose and titrate carefully, with an ECG and monitoring for extrapyramidal symptoms and sedation. Consider an alternative antipsychotic with less dependence on these enzymes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Haloperidol?
MediHelp rates the interaction as major. Cobicistat and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat is a strong CYP3A4 and CYP2D6 inhibitor and can raise haloperidol concentrations, increasing the risk of QT prolongation, sedation and extrapyramidal effects.
How serious is the interaction between Cobicistat and Haloperidol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start haloperidol at a low dose and titrate carefully, with an ECG and monitoring for extrapyramidal symptoms and sedation. Consider an alternative antipsychotic with less dependence on these enzymes.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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