Drug interactions
Cobicistat + Losartan
Severity: Minor
Cobicistat and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and may alter exposure to losartan and its active metabolite. The clinical significance is uncertain because losartan is mainly metabolized by CYP2C9 and CYP3A4.
What this interaction means in plain words
Cobicistat and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cobicistat belongs to Miscellaneous; Losartan belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by cobicistat may modestly alter losartan metabolism.
What to do
No empirical dose change is needed; monitor blood pressure when starting or stopping cobicistat.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Losartan?
MediHelp rates the interaction as minor. Cobicistat and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cobicistat is a strong CYP3A4 inhibitor and may alter exposure to losartan and its active metabolite. The clinical significance is uncertain because losartan is mainly metabolized by CYP2C9 and CYP3A4.
How serious is the interaction between Cobicistat and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor blood pressure when starting or stopping cobicistat.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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