Drug interactions
Cobicistat + Omeprazole
Severity: Minor
Cobicistat and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a potent CYP3A4 inhibitor, and CYP3A4 is a secondary route of omeprazole metabolism. Omeprazole levels may rise modestly, but omeprazole has a wide safety margin and the effect is usually of little consequence.
What this interaction means in plain words
Cobicistat and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cobicistat belongs to Miscellaneous; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Cobicistat inhibits CYP3A4, reducing a minor pathway of omeprazole clearance.
What to do
No routine dose change is needed at usual omeprazole doses. Review the omeprazole dose if high doses are used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Omeprazole?
MediHelp rates the interaction as minor. Cobicistat and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cobicistat is a potent CYP3A4 inhibitor, and CYP3A4 is a secondary route of omeprazole metabolism. Omeprazole levels may rise modestly, but omeprazole has a wide safety margin and the effect is usually of little consequence.
How serious is the interaction between Cobicistat and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed at usual omeprazole doses. Review the omeprazole dose if high doses are used long term.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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