Drug interactions
Cobicistat + Perphenazine
Severity: Moderate
Cobicistat and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4 and CYP2D6, and perphenazine is cleared mainly by CYP2D6. Perphenazine exposure may rise, increasing sedation, extrapyramidal symptoms and QT risk.
What this interaction means in plain words
Cobicistat and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobicistat belongs to Miscellaneous; Perphenazine belongs to Central Nervous System.
Why it happens
Cobicistat inhibits CYP2D6 and CYP3A4 metabolism of perphenazine.
What to do
Consider a lower perphenazine dose and monitor for extrapyramidal symptoms, sedation and QT changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Perphenazine?
MediHelp rates the interaction as moderate. Cobicistat and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat inhibits CYP3A4 and CYP2D6, and perphenazine is cleared mainly by CYP2D6. Perphenazine exposure may rise, increasing sedation, extrapyramidal symptoms and QT risk.
How serious is the interaction between Cobicistat and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower perphenazine dose and monitor for extrapyramidal symptoms, sedation and QT changes.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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