Drug interactions
Cobimetinib + Zileuton
Severity: Moderate
Cobimetinib and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zileuton is a weak CYP3A4 inhibitor and may modestly increase cobimetinib exposure. Higher cobimetinib levels could worsen toxicities such as rash, diarrhea, hemorrhage, liver injury and retinal disorders.
What this interaction means in plain words
Cobimetinib and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cobimetinib belongs to Oncology; Zileuton belongs to Respiratory.
Why it happens
Inhibition of CYP3A4 metabolism of cobimetinib by zileuton.
What to do
No fixed dose change is generally needed for a weak inhibitor, but monitor for cobimetinib adverse effects and liver enzymes. Reduce the dose or interrupt therapy if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Cobimetinib
- Cobimetinib + Efavirenz Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Amobarbital + Cobimetinib Major
- Apalutamide + Cobimetinib Major
- Aprepitant + Cobimetinib Major
- Bosentan + Cobimetinib Major
Frequently asked questions
Can I take Cobimetinib with Zileuton?
MediHelp rates the interaction as moderate. Cobimetinib and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zileuton is a weak CYP3A4 inhibitor and may modestly increase cobimetinib exposure. Higher cobimetinib levels could worsen toxicities such as rash, diarrhea, hemorrhage, liver injury and retinal disorders.
How serious is the interaction between Cobimetinib and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No fixed dose change is generally needed for a weak inhibitor, but monitor for cobimetinib adverse effects and liver enzymes. Reduce the dose or interrupt therapy if toxicity develops.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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