Drug interactions
Cocaine + Eletriptan
Severity: Moderate
Cocaine and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cocaine blocks monoamine reuptake and may add to eletriptan's serotonergic and vasoconstrictive effects. With topical medical use systemic exposure is low, but illicit use poses greater risk.
What this interaction means in plain words
Cocaine and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cocaine belongs to Central Nervous System; Eletriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects and vasoconstriction from cocaine reuptake inhibition combined with triptan agonism.
What to do
Avoid triptans in patients using cocaine recreationally. With topical medical use, monitor for serotonin syndrome and elevated blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Eletriptan?
MediHelp rates the interaction as moderate. Cocaine and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cocaine blocks monoamine reuptake and may add to eletriptan's serotonergic and vasoconstrictive effects. With topical medical use systemic exposure is low, but illicit use poses greater risk.
How serious is the interaction between Cocaine and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid triptans in patients using cocaine recreationally. With topical medical use, monitor for serotonin syndrome and elevated blood pressure.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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