Drug interactions
Cocaine + Ergotamine
Severity: Moderate
Cocaine and Ergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cocaine blocks monoamine reuptake and is a potent vasoconstrictor, while ergotamine also causes vasoconstriction. Together they could increase hypertension and ischemia risk, although with topical use systemic exposure is limited.
What this interaction means in plain words
Cocaine and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cocaine belongs to Central Nervous System; Ergotamine belongs to Central Nervous System.
Why it happens
Additive vasoconstriction and sympathomimetic effects from reuptake inhibition and ergot receptor agonism.
What to do
Avoid illicit cocaine use. For topical medical cocaine, monitor blood pressure and watch for ischemic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Ergotamine?
MediHelp rates the interaction as moderate. Cocaine and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cocaine blocks monoamine reuptake and is a potent vasoconstrictor, while ergotamine also causes vasoconstriction. Together they could increase hypertension and ischemia risk, although with topical use systemic exposure is limited.
How serious is the interaction between Cocaine and Ergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid illicit cocaine use. For topical medical cocaine, monitor blood pressure and watch for ischemic symptoms.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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