Drug interactions
Cocaine + Rizatriptan
Severity: Moderate
Cocaine and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cocaine blocks serotonin, dopamine and norepinephrine reuptake and causes vasoconstriction and hypertension. With rizatriptan, which is also vasoconstrictive, this could add to cardiovascular strain and theoretically raise serotonin toxicity risk. Systemic exposure from topical medical cocaine is limited, but illicit use carries greater risk.
What this interaction means in plain words
Cocaine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cocaine belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
Additive vasoconstrictive and serotonergic effects; cocaine inhibits monoamine reuptake while rizatriptan is a 5-HT1B/1D agonist.
What to do
Avoid rizatriptan in patients using cocaine recreationally because of coronary vasospasm and hypertension risk. For topical medical use, monitor blood pressure and for serotonin toxicity symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Rizatriptan?
MediHelp rates the interaction as moderate. Cocaine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cocaine blocks serotonin, dopamine and norepinephrine reuptake and causes vasoconstriction and hypertension. With rizatriptan, which is also vasoconstrictive, this could add to cardiovascular strain and theoretically raise serotonin toxicity risk. Systemic exposure from topical medical cocaine is limited, but illicit use carries greater risk.
How serious is the interaction between Cocaine and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid rizatriptan in patients using cocaine recreationally because of coronary vasospasm and hypertension risk. For topical medical use, monitor blood pressure and for serotonin toxicity symptoms.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
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