Drug interactions
Cocaine + Trazodone
Severity: Moderate
Cocaine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cocaine blocks reuptake of serotonin, norepinephrine and dopamine, and may add to trazodone's serotonergic effects, as well as cardiovascular stimulation and arrhythmia risk. When cocaine is used topically as a local anesthetic, systemic absorption is limited, and the risk is correspondingly lower.
What this interaction means in plain words
Cocaine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cocaine belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive monoamine reuptake inhibition and serotonergic effects, with sympathomimetic cardiovascular stimulation.
What to do
Monitor blood pressure, heart rate and signs of serotonin toxicity, and use the smallest effective dose of topical cocaine. Avoid illicit cocaine use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Trazodone?
MediHelp rates the interaction as moderate. Cocaine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cocaine blocks reuptake of serotonin, norepinephrine and dopamine, and may add to trazodone's serotonergic effects, as well as cardiovascular stimulation and arrhythmia risk. When cocaine is used topically as a local anesthetic, systemic absorption is limited, and the risk is correspondingly lower.
How serious is the interaction between Cocaine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and signs of serotonin toxicity, and use the smallest effective dose of topical cocaine. Avoid illicit cocaine use.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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