Drug interactions
Cocaine + Trimipramine
Severity: Moderate
Cocaine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical cocaine used as a local anesthetic has low systemic absorption, but tricyclics block catecholamine reuptake and may potentiate its sympathomimetic effects. Hypertension and arrhythmias are possible, particularly with larger doses or mucosal application.
What this interaction means in plain words
Cocaine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cocaine belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive inhibition of norepinephrine reuptake enhancing sympathomimetic effects.
What to do
Use the smallest effective cocaine dose and monitor blood pressure and heart rhythm. Choose an alternative local anesthetic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cocaine and Trimipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Trimipramine?
MediHelp rates the interaction as moderate. Cocaine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topical cocaine used as a local anesthetic has low systemic absorption, but tricyclics block catecholamine reuptake and may potentiate its sympathomimetic effects. Hypertension and arrhythmias are possible, particularly with larger doses or mucosal application.
How serious is the interaction between Cocaine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the smallest effective cocaine dose and monitor blood pressure and heart rhythm. Choose an alternative local anesthetic where possible.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
