Drug interactions
Cocaine + Vortioxetine
Severity: Moderate
Cocaine and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cocaine, including topical use, has been reported to inhibit CYP2D6 and also blocks monoamine reuptake. Vortioxetine is metabolized mainly by CYP2D6, so exposure may rise. Cocaine's serotonergic effects add to the risk of serotonin toxicity, though topical use gives limited systemic exposure.
What this interaction means in plain words
Cocaine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cocaine belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition may raise vortioxetine levels, with additive monoamine reuptake inhibition.
What to do
Avoid recreational or systemic cocaine. For brief topical medical use, monitor for vortioxetine adverse effects such as nausea and serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Cocaine
- Cocaine + Isocarboxazid Contraindicated
- Cocaine + Phenelzine Contraindicated
- Cocaine + Procarbazine Contraindicated
- Amitriptyline + Cocaine Major
- Bisoprolol + Cocaine Major
- Citalopram + Cocaine Major
Frequently asked questions
Can I take Cocaine with Vortioxetine?
MediHelp rates the interaction as moderate. Cocaine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cocaine, including topical use, has been reported to inhibit CYP2D6 and also blocks monoamine reuptake. Vortioxetine is metabolized mainly by CYP2D6, so exposure may rise. Cocaine's serotonergic effects add to the risk of serotonin toxicity, though topical use gives limited systemic exposure.
How serious is the interaction between Cocaine and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid recreational or systemic cocaine. For brief topical medical use, monitor for vortioxetine adverse effects such as nausea and serotonin toxicity.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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