Drug interactions
Codeine + Dantrolene
Severity: Moderate
Codeine and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene commonly causes drowsiness and dizziness, which add to the sedative effect of codeine. Oral dantrolene also carries a hepatotoxicity risk that is unrelated to this interaction.
What this interaction means in plain words
Codeine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Codeine belongs to Musculoskeletal; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for oversedation and impaired psychomotor function, and reduce the codeine dose if needed. Advise patients to avoid driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Dantrolene
Frequently asked questions
Can I take Codeine with Dantrolene?
MediHelp rates the interaction as moderate. Codeine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene commonly causes drowsiness and dizziness, which add to the sedative effect of codeine. Oral dantrolene also carries a hepatotoxicity risk that is unrelated to this interaction.
How serious is the interaction between Codeine and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and impaired psychomotor function, and reduce the codeine dose if needed. Advise patients to avoid driving until tolerance is established.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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