Drug interactions
Codeine + Fedratinib
Severity: Moderate
Codeine and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP2D6 inhibitor and may reduce conversion of codeine to morphine. This can lower analgesic effect, while the effect on adverse outcomes is less certain.
What this interaction means in plain words
Codeine and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Codeine belongs to Musculoskeletal; Fedratinib belongs to Oncology.
Why it happens
Inhibition of CYP2D6 by fedratinib reduces formation of the active metabolite morphine from codeine.
What to do
Monitor for reduced pain relief and consider a non-CYP2D6-dependent analgesic if control is inadequate. Reassess if fedratinib is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Codeine with Fedratinib?
MediHelp rates the interaction as moderate. Codeine and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP2D6 inhibitor and may reduce conversion of codeine to morphine. This can lower analgesic effect, while the effect on adverse outcomes is less certain.
How serious is the interaction between Codeine and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced pain relief and consider a non-CYP2D6-dependent analgesic if control is inadequate. Reassess if fedratinib is started or stopped.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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