Drug interactions
Codeine + Modafinil
Severity: Minor
Codeine and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil may induce CYP3A4 and could slightly alter codeine metabolism toward norcodeine, with an unclear net effect on analgesia. Its wakefulness-promoting action does not reliably reverse opioid sedation or respiratory depression.
What this interaction means in plain words
Codeine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Codeine belongs to Musculoskeletal; Modafinil belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 induction altering codeine metabolism; effect not well established.
What to do
No routine adjustment is needed; monitor analgesic response and sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Modafinil
Frequently asked questions
Can I take Codeine with Modafinil?
MediHelp rates the interaction as minor. Codeine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil may induce CYP3A4 and could slightly alter codeine metabolism toward norcodeine, with an unclear net effect on analgesia. Its wakefulness-promoting action does not reliably reverse opioid sedation or respiratory depression.
How serious is the interaction between Codeine and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor analgesic response and sedation.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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