Drug interactions
Codeine + Ozanimod
Severity: Moderate
Codeine and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's metabolites inhibit MAO-B in vitro, and opioids with serotonergic activity are cautioned with MAO inhibitors. Codeine has weak serotonergic effects, so serotonin syndrome or blood pressure changes are possible but uncertain.
What this interaction means in plain words
Codeine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Codeine belongs to Musculoskeletal; Ozanimod belongs to Central Nervous System.
Why it happens
Possible MAO inhibition by ozanimod metabolites combined with weak serotonergic or adrenergic effects of codeine.
What to do
Monitor blood pressure and for serotonergic symptoms such as agitation, tremor and hyperthermia. Use an alternative analgesic if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Codeine with Ozanimod?
MediHelp rates the interaction as moderate. Codeine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's metabolites inhibit MAO-B in vitro, and opioids with serotonergic activity are cautioned with MAO inhibitors. Codeine has weak serotonergic effects, so serotonin syndrome or blood pressure changes are possible but uncertain.
How serious is the interaction between Codeine and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for serotonergic symptoms such as agitation, tremor and hyperthermia. Use an alternative analgesic if symptoms appear.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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