Drug interactions
Codeine + Risperidone
Severity: Moderate
Codeine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause sedation and orthostatic hypotension, which add to the CNS and respiratory depression of codeine. Patients, particularly older adults, may have increased drowsiness, dizziness and falls.
What this interaction means in plain words
Codeine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Codeine belongs to Musculoskeletal; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotensive effects.
What to do
Use the lowest effective doses and monitor for sedation and orthostatic hypotension. Take extra care in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Codeine with Risperidone?
MediHelp rates the interaction as moderate. Codeine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can cause sedation and orthostatic hypotension, which add to the CNS and respiratory depression of codeine. Patients, particularly older adults, may have increased drowsiness, dizziness and falls.
How serious is the interaction between Codeine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and orthostatic hypotension. Take extra care in elderly patients.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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