Drug interactions
Codeine + Stiripentol
Severity: Moderate
Codeine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol causes somnolence and can add to opioid-induced sedation and respiratory depression. Stiripentol also inhibits several CYP enzymes, including CYP2D6 and CYP3A4, which may alter codeine metabolism and analgesic effect.
What this interaction means in plain words
Codeine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Codeine belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression plus stiripentol inhibition of CYP enzymes involved in codeine metabolism.
What to do
Monitor for sedation, respiratory depression and reduced analgesic effect, and use the lowest effective codeine dose. Counsel patients to avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Codeine and Stiripentol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Codeine with Stiripentol?
MediHelp rates the interaction as moderate. Codeine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol causes somnolence and can add to opioid-induced sedation and respiratory depression. Stiripentol also inhibits several CYP enzymes, including CYP2D6 and CYP3A4, which may alter codeine metabolism and analgesic effect.
How serious is the interaction between Codeine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression and reduced analgesic effect, and use the lowest effective codeine dose. Counsel patients to avoid alcohol and other sedatives.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
