Drug interactions
Codeine + Trimipramine
Severity: Moderate
Codeine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a sedating tricyclic antidepressant, and with codeine can cause additive CNS and respiratory depression. Its anticholinergic effects may add to opioid constipation and urinary retention, and its CYP2D6 metabolism and weak inhibition may alter effects.
What this interaction means in plain words
Codeine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Codeine belongs to Musculoskeletal; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects, with possible CYP2D6 competition.
What to do
Start with low doses and monitor sedation, respiratory rate and anticholinergic effects. Adjust therapy if sedation or constipation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Codeine with Trimipramine?
MediHelp rates the interaction as moderate. Codeine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a sedating tricyclic antidepressant, and with codeine can cause additive CNS and respiratory depression. Its anticholinergic effects may add to opioid constipation and urinary retention, and its CYP2D6 metabolism and weak inhibition may alter effects.
How serious is the interaction between Codeine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor sedation, respiratory rate and anticholinergic effects. Adjust therapy if sedation or constipation is excessive.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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