Drug interactions
Colchicine + Glycerol phenylbutyrate
Severity: Minor
Colchicine and Glycerol phenylbutyrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycerol phenylbutyrate is a weak CYP3A4 inducer and may modestly lower colchicine exposure. The clinical impact is likely small but could reduce anti-inflammatory efficacy.
What this interaction means in plain words
Colchicine and Glycerol phenylbutyrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colchicine belongs to Genitourinary; Glycerol phenylbutyrate belongs to Miscellaneous.
Why it happens
Weak induction of CYP3A4 may increase colchicine metabolism.
What to do
Monitor colchicine efficacy and adjust the dose if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Major
- Glycerol phenylbutyrate + Valproic acid Major
- Cyclosporin + Glycerol phenylbutyrate Moderate
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderate
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderate
- Fludrocortisone + Glycerol phenylbutyrate Moderate
Frequently asked questions
Can I take Colchicine with Glycerol phenylbutyrate?
MediHelp rates the interaction as minor. Colchicine and Glycerol phenylbutyrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glycerol phenylbutyrate is a weak CYP3A4 inducer and may modestly lower colchicine exposure. The clinical impact is likely small but could reduce anti-inflammatory efficacy.
How serious is the interaction between Colchicine and Glycerol phenylbutyrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor colchicine efficacy and adjust the dose if response is inadequate.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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