Drug interactions
Colchicine + Istradefylline
Severity: Moderate
Colchicine and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily, istradefylline raises exposure to CYP3A4 and P-gp substrates, which may increase colchicine levels and toxicity. The effect was not seen at 20 mg daily.
What this interaction means in plain words
Colchicine and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline at higher doses inhibits CYP3A4 and P-glycoprotein, reducing colchicine clearance.
What to do
Monitor for colchicine toxicity and consider reducing the colchicine dose, particularly if istradefylline 40 mg/day is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Colchicine with Istradefylline?
MediHelp rates the interaction as moderate. Colchicine and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At 40 mg daily, istradefylline raises exposure to CYP3A4 and P-gp substrates, which may increase colchicine levels and toxicity. The effect was not seen at 20 mg daily.
How serious is the interaction between Colchicine and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for colchicine toxicity and consider reducing the colchicine dose, particularly if istradefylline 40 mg/day is used.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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