Drug interactions
Colchicine + Olutasidenib
Severity: Moderate
Colchicine and Olutasidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olutasidenib induces CYP3A4 and may lower colchicine exposure, which could reduce its effectiveness in gout flares, prophylaxis or familial Mediterranean fever. Olutasidenib may also affect P-gp, so the net effect on colchicine is not fully predictable.
What this interaction means in plain words
Colchicine and Olutasidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Olutasidenib belongs to Oncology.
Why it happens
Induction of CYP3A4 (and possibly P-glycoprotein) by olutasidenib increases colchicine clearance.
What to do
Monitor for loss of colchicine efficacy and adjust therapy if symptoms recur. Consider an alternative agent if a reliable colchicine effect is essential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Olutasidenib
Frequently asked questions
Can I take Colchicine with Olutasidenib?
MediHelp rates the interaction as moderate. Colchicine and Olutasidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olutasidenib induces CYP3A4 and may lower colchicine exposure, which could reduce its effectiveness in gout flares, prophylaxis or familial Mediterranean fever. Olutasidenib may also affect P-gp, so the net effect on colchicine is not fully predictable.
How serious is the interaction between Colchicine and Olutasidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of colchicine efficacy and adjust therapy if symptoms recur. Consider an alternative agent if a reliable colchicine effect is essential.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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