Drug interactions
Colesevelam + Glibenclamide
Severity: Moderate
Colesevelam and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam can bind glyburide in the gut and reduce how much is absorbed when both are taken together. This may lead to weaker glycemic control. Glyburide absorption is not meaningfully reduced when it is taken well before colesevelam.
What this interaction means in plain words
Colesevelam and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colesevelam belongs to Endocrine; Glibenclamide belongs to Endocrine.
Why it happens
Bile acid sequestrant binds glyburide in the gastrointestinal tract, reducing its absorption.
What to do
Give glyburide at least 4 hours before colesevelam. Monitor blood glucose if dosing times cannot be separated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Gliclazide Moderate
Frequently asked questions
Can I take Colesevelam with Glibenclamide?
MediHelp rates the interaction as moderate. Colesevelam and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colesevelam can bind glyburide in the gut and reduce how much is absorbed when both are taken together. This may lead to weaker glycemic control. Glyburide absorption is not meaningfully reduced when it is taken well before colesevelam.
How serious is the interaction between Colesevelam and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give glyburide at least 4 hours before colesevelam. Monitor blood glucose if dosing times cannot be separated.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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