Drug interactions
Colesevelam + Glimepiride-pioglitazone
Severity: Moderate
Colesevelam and Glimepiride-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam binds glimepiride in the gut when both are taken together and lowers its absorption, which may weaken glucose control. Absorption is not meaningfully reduced if glimepiride is taken well before colesevelam.
What this interaction means in plain words
Colesevelam and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colesevelam belongs to Endocrine; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Bile acid sequestrant binds glimepiride in the gastrointestinal tract, reducing absorption.
What to do
Give glimepiride at least 4 hours before colesevelam. Monitor blood glucose if the dosing schedule changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Frequently asked questions
Can I take Colesevelam with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Colesevelam and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colesevelam binds glimepiride in the gut when both are taken together and lowers its absorption, which may weaken glucose control. Absorption is not meaningfully reduced if glimepiride is taken well before colesevelam.
How serious is the interaction between Colesevelam and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give glimepiride at least 4 hours before colesevelam. Monitor blood glucose if the dosing schedule changes.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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