Drug interactions
Colesevelam + Maralixibat
Severity: Moderate
Colesevelam and Maralixibat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam binds bile acids and can bind maralixibat in the gut, reducing its effect. This may reduce control of cholestatic pruritus.
What this interaction means in plain words
Colesevelam and Maralixibat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colesevelam belongs to Endocrine; Maralixibat belongs to Gastrointestinal Tract.
Why it happens
Binding of maralixibat in the gastrointestinal lumen reduces its availability for IBAT inhibition.
What to do
Give maralixibat at least 4 hours before or after colesevelam. Monitor pruritus and serum bile acids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maralixibat
- Cholestyramine + Maralixibat Moderate
- Colestipol + Maralixibat Moderate
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Frequently asked questions
Can I take Colesevelam with Maralixibat?
MediHelp rates the interaction as moderate. Colesevelam and Maralixibat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colesevelam binds bile acids and can bind maralixibat in the gut, reducing its effect. This may reduce control of cholestatic pruritus.
How serious is the interaction between Colesevelam and Maralixibat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give maralixibat at least 4 hours before or after colesevelam. Monitor pruritus and serum bile acids.
What other medicines interact with Maralixibat?
MediHelp also lists interactions of Maralixibat with, for example, Cholestyramine, Colestipol. The full list is on the Maralixibat page.
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