Drug interactions
Colesevelam + Metformin-sitagliptin
Severity: Minor
Colesevelam and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam can lower glucose by itself, so the combination may enhance glycemic effect. Bile acid sequestrants may also bind some coadministered drugs in the gut, although a clear metformin effect is not established.
What this interaction means in plain words
Colesevelam and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colesevelam belongs to Endocrine; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Additive glucose lowering; possible reduced absorption of drugs bound in the gut, though not well established for metformin.
What to do
Monitor blood glucose when starting or stopping colesevelam. Separate dosing by a few hours if absorption concerns arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Frequently asked questions
Can I take Colesevelam with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Colesevelam and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Colesevelam can lower glucose by itself, so the combination may enhance glycemic effect. Bile acid sequestrants may also bind some coadministered drugs in the gut, although a clear metformin effect is not established.
How serious is the interaction between Colesevelam and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping colesevelam. Separate dosing by a few hours if absorption concerns arise.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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