Drug interactions
Colesevelam + Olmesartan
Severity: Moderate
Colesevelam and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam is a bile acid sequestrant that can bind olmesartan in the gut and lower its absorption. This may reduce olmesartan exposure and blunt its blood pressure lowering effect.
What this interaction means in plain words
Colesevelam and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colesevelam belongs to Endocrine; Olmesartan belongs to Cardiovascular.
Why it happens
Colesevelam binds olmesartan medoxomil in the gastrointestinal tract, reducing its absorption.
What to do
Give olmesartan at least 4 hours before colesevelam. Monitor blood pressure if the two are taken close together.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Frequently asked questions
Can I take Colesevelam with Olmesartan?
MediHelp rates the interaction as moderate. Colesevelam and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colesevelam is a bile acid sequestrant that can bind olmesartan in the gut and lower its absorption. This may reduce olmesartan exposure and blunt its blood pressure lowering effect.
How serious is the interaction between Colesevelam and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give olmesartan at least 4 hours before colesevelam. Monitor blood pressure if the two are taken close together.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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