Drug interactions
Colestipol + Mycophenolate mofetil
Severity: Moderate
Colestipol and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol binds mycophenolic acid and interrupts its enterohepatic recirculation, lowering mycophenolate exposure. This may reduce immunosuppressive efficacy and risk rejection.
What this interaction means in plain words
Colestipol and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Colestipol, a bile acid sequestrant, binds mycophenolate in the gut and reduces absorption and enterohepatic recycling.
What to do
Avoid concurrent dosing if possible; if colestipol is needed, give mycophenolate at least 1 hour before or 4 to 6 hours after colestipol and monitor for loss of effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Colestipol and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol binds mycophenolic acid and interrupts its enterohepatic recirculation, lowering mycophenolate exposure. This may reduce immunosuppressive efficacy and risk rejection.
How serious is the interaction between Colestipol and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent dosing if possible; if colestipol is needed, give mycophenolate at least 1 hour before or 4 to 6 hours after colestipol and monitor for loss of effect.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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