Drug interactions
Colestipol + Obeticholic acid
Severity: Moderate
Colestipol and Obeticholic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bile acid sequestrants bind obeticholic acid in the gut and reduce its absorption, which may lessen its therapeutic effect in cholestatic liver disease.
What this interaction means in plain words
Colestipol and Obeticholic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Obeticholic acid belongs to Gastrointestinal Tract.
Why it happens
Colestipol binds obeticholic acid in the gastrointestinal lumen, reducing absorption.
What to do
Give obeticholic acid at least 4 hours before or 4 hours after colestipol. Monitor liver biochemistry and response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Obeticholic acid
- Cholestyramine + Obeticholic acid Moderate
- Colesevelam + Obeticholic acid Moderate
- Obeticholic acid + Theophylline Moderate
- Obeticholic acid + Tizanidine Moderate
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Obeticholic acid?
MediHelp rates the interaction as moderate. Colestipol and Obeticholic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bile acid sequestrants bind obeticholic acid in the gut and reduce its absorption, which may lessen its therapeutic effect in cholestatic liver disease.
How serious is the interaction between Colestipol and Obeticholic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give obeticholic acid at least 4 hours before or 4 hours after colestipol. Monitor liver biochemistry and response.
What other medicines interact with Obeticholic acid?
MediHelp also lists interactions of Obeticholic acid with, for example, Cholestyramine, Colesevelam, Theophylline. The full list is on the Obeticholic acid page.
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