Drug interactions
Obeticholic acid + Tizanidine
Severity: Moderate
Obeticholic acid and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Obeticholic acid weakly inhibits CYP1A2, the main enzyme that clears tizanidine. Higher tizanidine levels may cause more hypotension, bradycardia, and sedation.
What this interaction means in plain words
Obeticholic acid and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Obeticholic acid belongs to Gastrointestinal Tract; Tizanidine belongs to Musculoskeletal.
Why it happens
Inhibition of CYP1A2-mediated metabolism of tizanidine by obeticholic acid.
What to do
Monitor blood pressure, heart rate and sedation, and reduce the tizanidine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Obeticholic acid
- Cholestyramine + Obeticholic acid Moderate
- Colesevelam + Obeticholic acid Moderate
- Colestipol + Obeticholic acid Moderate
- Obeticholic acid + Theophylline Moderate
Frequently asked questions
Can I take Obeticholic acid with Tizanidine?
MediHelp rates the interaction as moderate. Obeticholic acid and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Obeticholic acid weakly inhibits CYP1A2, the main enzyme that clears tizanidine. Higher tizanidine levels may cause more hypotension, bradycardia, and sedation.
How serious is the interaction between Obeticholic acid and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sedation, and reduce the tizanidine dose if adverse effects occur.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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