Drug interactions
Colesevelam + Obeticholic acid
Severity: Moderate
Colesevelam and Obeticholic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bile acid sequestrants bind obeticholic acid in the gut, reducing its absorption and potentially its effectiveness in liver disease. Efficacy may be diminished if doses are taken close together.
What this interaction means in plain words
Colesevelam and Obeticholic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colesevelam belongs to Endocrine; Obeticholic acid belongs to Gastrointestinal Tract.
Why it happens
Colesevelam binds obeticholic acid in the gastrointestinal tract, reducing its absorption.
What to do
Give obeticholic acid at least 4 hours before or 4 hours after colesevelam, and monitor liver biochemistry response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Cyclosporine Moderate
Other interactions of Obeticholic acid
- Cholestyramine + Obeticholic acid Moderate
- Colestipol + Obeticholic acid Moderate
- Obeticholic acid + Theophylline Moderate
- Obeticholic acid + Tizanidine Moderate
Frequently asked questions
Can I take Colesevelam with Obeticholic acid?
MediHelp rates the interaction as moderate. Colesevelam and Obeticholic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bile acid sequestrants bind obeticholic acid in the gut, reducing its absorption and potentially its effectiveness in liver disease. Efficacy may be diminished if doses are taken close together.
How serious is the interaction between Colesevelam and Obeticholic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give obeticholic acid at least 4 hours before or 4 hours after colesevelam, and monitor liver biochemistry response.
What other medicines interact with Colesevelam?
MediHelp also lists interactions of Colesevelam with, for example, Amlodipine-olmesartan-hydrochlorothiazide, Amlodipine-olmesartan, Chenodiol. The full list is on the Colesevelam page.
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